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. 2022 Jun 1;79(6):331. doi: 10.1007/s00018-022-04347-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Administration of recombinant IL-21 enhances Aβ deposition in the brains of 5xFAD mice. Mice were given five injections of IL-21 or four injections of anti-IL-21R antibody (IL-21R blocker) and Aβ plaques were stained in the brain using thioflavin-S. Accumulation of plaques in—A vehicle-injected control; B IL-21 injected; C IL-21R blocker injected; D bar graph depicts the quantitation of the same in both males and females. N = 14