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. 2022 Apr 11;39(5):935–948. doi: 10.1007/s11095-022-03245-7

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© The Author(s) 2022

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Fig. 1 — Representative averaged Raman spectrum of an acyclovir cream, 5% product (Zovirax^® UK Pump, (a) and of polymorphic forms I, II and V of acyclovir as well as of an acyclovir crystal within a commercial cream product (Zovirax^® UK Pump, (b). The highlighted region marks Raman peaks associated with the putative penetration enhancer propylene glycol (840 cm⁻¹) and peaks significant for the distinction of the different polymorphs of acyclovir (650 cm⁻¹), respectively.