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In silico absorption and toxicity profile of the compounds as obtained from the AdmetSar server.
| Absorption/toxicity profile | Value | Probability |
|---|---|---|
| Human blood-brain barrier (BBB) | − | 0.9570 |
| Intestinal absorption (HIA) | + | 0.8161 |
| Caco-2 | − | 0.8816 |
| Plasma protein binding | 1.096436381 | 1.00 |
| AMES Test | − | 0.6600 |
| Carcinogenicity | − | 0.9714 |
| UGT catalysed | + | 0.6000 |
| Acute oral toxicity (LD50; kg/mol) | 2.257 | |
| Hepatotoxicity | + | 0.6500 |
