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. 2022 May 19;13:818173. doi: 10.3389/fimmu.2022.818173

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Copyright © 2022 Wu, Zeng, Ou, Wang, Chen and Nandakumar

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Estrogen promoted psoriasis symptoms were dependent on IL23/IL-17 axis. Expression of (A) IL-6, (B) TNF-α, (C) IL-22, (D) IL-23, (E) IL-17A, (F) IL-17E, and (G) IL-17F cytokines in male, female, OVX and sham operated, E2 or miglyol, PHTPP or DPN treated mice with and without mannan stimulation (n = 5/group). Man, mannan; MM, Man + Male; MF, Man + Female; MO, Man + OVX; MS, Man + Sham; Mig, miglyol; E2, 17-β-estradiol; Oil (P), E2 + Corn oil + Man; PHTPP, E2 + PHTPP +Man; Oil (D), Corn oil + Man; DPN, DPN + Man. Statistical analyses were performed using an unpaired t test and n indicates number of mice. The data represent mean ± SEM. ns, not significant. *p < 0.05; **p < 0.01. ***p < 0.001.