Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 1;12:9099. doi: 10.1038/s41598-022-13052-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Platelet activation signaling pathway. (1) Platelets can be activated via two ways: (A) The GPVI receptor on platelets’ surface binds to collagen fibers in the ECM of tumor tissue; (B) Platelets can also be activated through binding to thrombin, which is produced by cancer cells via PAR-1 receptors on the platelets’ surface. Activated platelets can promote tumor metastasis via different ways. (2) They can also release different cytokines that impair NK cell’s function. These cytokines also can help tumor cell growth and vascularization. (3) They can cover up metastatic cells in collaboration with fibrinogen fibers helping metastatic cells to escape from the immune system. *NK: natural killer; GPVI: glycoprotein VI.