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. 2022 Jun 1;13:3055. doi: 10.1038/s41467-022-30641-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — In silico analysis of cytokinesis and mitotic spindle assembly genes (a) or differentiation genes (b) of KDM5B- and H3K4me3-ChIPseq data from breast cancer cell lines SUM185, SUM159, MCF7, HCC2157, T47D, and MDA231 (GSE46073⁴²) and melanoma cell lines MM27, MM13, MM16 (GSE71854⁴⁴) and A375 (GSE99835⁴³)) and ChIP-Atlas⁴¹. c KDM5B knockdown in MaMel63a cells was confirmed by immunoblotting 4 days after siRNA transfection. d KDM5B target gene expression of cytokinesis-related genes (AURKB, KIF4A) and differentiation-related genes (DCT, MelanA) was analyzed by qPCR 4 days after KDM5B knockdown and 3 days of Neg4 or Cpd1 treatment (10 µM). Shown is one representative example (mean ± SD, n = 2). Source data are provided as a Source Data file.