Skip to main content
. 2022 May 19;9:879209. doi: 10.3389/fcvm.2022.879209

Figure 2.

Figure 2

(A) Representative images of mitochondrial morphology and distribution in heart slices by transmission electron microscopy. White arrows indicate damaged mitochondria in DCM heart slices (10,000× magnification, scale bar = 500 nm). (B) Mitochondrial circularity score. (C) Mitochondrial cristae disruption score. (D) Average number of mitochondrial inclusion bodies. Specific enzymatic activities of mitochondrial electron transport chain (E) complex I; (F) complex II; and (G) citrate synthase in nmol/(min*mg) protein. (H) Relative ATP to ADP ratio in LV tissue. (I) Mitochondrial oxygen consumption represented by the respiratory control ratio (RCR) in basal and ADP-stimulated cardiac fibers. Data are expressed as mean ± SEM and analyzed using one-way ANOVA with Tukey's multiple comparisons test (each individual patient heart = n, male NFC n = 6, female NFC n = 6, male DCM n = 6, female DCM n = 6, *p < 0.05 vs. NFC).