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. 2022 May 19;12:794170. doi: 10.3389/fcimb.2022.794170

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Copyright © 2022 Wu, Yang, Fan, Guo, Li, Gu, Zhang, Gao, Liu and Yin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional profiling performed with PICRUSt2. LEfSe analysis of differential functional abundance based on the KEGG pathway map. (A) TPOAb-positive vs. TPOAb-negative women with SCH and no LT₄; (B) TPOAb-positive vs. TPOAb-negative women with SCH and low-dose LT₄; (C) TPOAb-positive vs. TPOAb-negative women with SCH and high-dose LT₄. LDA value distribution histogram: the red and green bars represented metabolic functions with higher abundance. A1, TPOAb-positive women with SCH and no LT₄; A2, TPOAb-positive women with SCH and low-dose LT₄; A3, TPOAb-positive women with SCH and high-dose LT₄; B1, TPOAb-negative women with SCH and no LT₄; B2, TPOAb-negative women with SCH and low-dose LT₄; B3, TPOAb-negative women with SCH and high-dose LT₄.