Table 1.
Demographic and clinical characteristics of the study participants.
| Characteristic | TPOAb-positive women with SCH (n = 75) | TPOAb-negative women with SCH (n = 90) | P value |
|---|---|---|---|
| General information | |||
| Han ethnicity, n (%) | 69 (92.0) | 81 (90.0) | 0.656 |
| Education background (postgraduate and above), n (%) |
16 (21.3) | 21 (23.3) | 0.846 |
| Education background (undergraduate), n (%) |
42 (56.0) | 45 (50.0) | |
| Education background (college and below), n (%) |
17 (22.7) | 24 (26.7) | |
| Family income (over 4×105yuan/year), n (%) |
22 (29.3) | 25 (27.8) | 0.925 |
| Family income (105to 4×105yuan/year), n (%) |
44 (58.7) | 55 (61.1) | |
| Family income (less than 105 yuan/year), n (%) |
9 (12.0) | 10 (11.1) | |
| first pregnancy, n (%) | 41 (54.7) | 52 (57.8) | 0.688 |
| Thyroid disease history, n (%) | 31 (41.3) | 13 (14.4) | 0.000 |
| Natural pregnancy, n (%) | 73 (97.3) | 86 (95.6) | 0.544 |
| Smoking, n (%) | 4 (5.3) | 6 (6.7) | 0.721 |
| drinking, n (%) | 5 (6.7) | 4 (4.4) | 0.531 |
| Indicator in the first trimester | |||
| Sickness, n (%) | 25 (33.3) | 41 (45.6) | 0.111 |
| Animals exposure, n (%) | 11 (14.7) | 16 (17.8) | 0.591 |
| Age (year), median (IQR) | 33 (30-37) | 33 (31-34) | 0.623 |
| BMI (kg/m2), median (IQR) | 21.6 (20.1-24.6) | 21.7 (19.9-25.3) | 0.961 |
| SBP (mmHg), median (IQR) | 112 (104-120) | 110 (101-117) | 0.153 |
| DBP (mmHg), mean ± SD | 67 ± 11 | 65 ± 9 | 0.193 |
| ALT (U/L), median (IQR) | 12.20 (9.70-20.60) | 12.30 (9.78-17.43) | 0.766 |
| AST (U/L), median (IQR) | 14.40 (13.00-17.30) | 15.05 (12.68-16.93) | 0.889 |
| ALB (g/L), mean ± SD | 43.96 ± 2.50 | 43.45 ± 1.91 | 0.188 |
| GLU (mmol/L), median (IQR) | 4.63 (4.49-4.93) | 4.65 (4.45-4.84) | 0.496 |
| BUN (mmol/L), mean ± SD | 3.11 ± 0.69 | 2.96 ± 0.56 | 0.116 |
| UA (µmol/L), median (IQR) | 214.30 (186.00-255.30) | 213.70 (183.05-252.48) | 0.973 |
| CRE (µmol/L), mean ± SD | 49.37 ± 6.76 | 48.70 ± 5.76 | 0.491 |
| TC (mmol/L), median (IQR) | 4.34 (3.84-4.85) | 4.06 (3.74-4.54) | 0.022 |
| TG (mmol/L), median (IQR) | 1.02 (0.70-1.40) | 1.00 (0.78-1.44) | 0.855 |
| HDL-C (mmol/L), median (IQR) | 1.54 (1.33-1.76) | 1.42 (1.25-1.59) | 0.093 |
| LDL-C (mmol/L), median (IQR) | 2.28 (1.93-2.79) | 2.10 (1.89-2.46) | 0.064 |
| HGB (g/L), mean ± SD | 130 ± 10 | 129 ± 10 | 0.572 |
IQR, interquartile range; TPOAb, thyroid peroxidase antibody; BMI, body mass index; SBP, systolicblood pressure; DBP, diastolic blood pressure; ALT, Alanine aminotransferase; AST, Aspartic acid aminotransferase; ALB, albumin; GLU, blood glucose; BUN, blood urea nitrogen; UA, uric acid; CRE, creatinine; TC, total cholesterol; TG, triglycerides; HDL-C, high-density lipoprotein-cholesterol; LDL-C, low-density lipoprotein-cholesterol; HGB, hemoglobin.
P<0.05 was considered a statistically significant difference.