TABLE 3.
Group comparison of haplotype and diplotype for CYP2C:TG between reference population and cases (overall and within subgroups).
| Group/Reference | Total (N = 55) | With objective a GERD Evidence (N = 39) | Without objective a GERD Evidence (N = 16) | Reference population, cohort 1 (N = 179) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Observations (haplotype and diplotype) | Total TG | TG hetero-zygotes | TG homo-zygotes | Total TG | TG hetero-zygotes | TG homo-zygotes | Total TG | TG hetero-zygotes | TG homo-zygotes | Total TG | TG hetero-zygotes | TG homo-zygotes |
| Count observed | 30 | 16 | 7 | 22 | 10 | 6 | 8 | 6 | 1 | 76 | 58 | 9 |
| Total count | 110 | 55 | 55 | 78 | 39 | 39 | 32 | 16 | 16 | 358 | 179 | 179 |
| Frequency (%) | 27.3 | 29 | 12.7 | 28.2 | 25.6 | 15.4 | 25 | 37.5 | 6.25 | 21.2 | 32.4 | 5.0 |
| b p-value | 0.19 | 0.74 | 0.06 | 0.18 | 0.45 | *0.03 | 0.65 | 0.78 | 0.58 | N/A | N/A | N/A |
a
Gastroesophageal reflux disease.
b
Compared with the reference population.
*p-value < 0.05.