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. 2022 May 19;10:828300. doi: 10.3389/fped.2022.828300

TABLE 1.

Prevalence of different subtypes of congenital heart disease by birth weight (average prevalence from 2014 to 2020).

Subgroup Total Grouped by birth weight
 Grouped by birth weight and gestational age
<1500 g
 1500∼2500 g
 2500∼4000 g
 ≥4000 g
 P value SGA
 AGA
 LGA
 P value
n ‰ n ‰ n ‰ n ‰ n ‰ n ‰ n ‰ n ‰
ASD/Q21.102 1994 2.75 57 3.55a,c 39 1.70a,e 1635 2.52f 32 0.87c,e,f <0.001 289 2.57➀,➁ 1191 2.11➀,➂ 52 1.09➁,➂ <0.001
VSD/Q21.001 1865 2.57 68 4.23a,b,c 38 1.66a 1480 2.28b,f 36 0.98c,f <0.001 246 2.19➁ 1085 1.92➂ 62 1.30➁,➂ 0.001
PFO/Q21.103 813 1.12 17 1.06a 65 2.84a,d,e 818 1.26d 49 1.33e <0.001 188 1.67➀ 564 1.00➀,➂ 88 1.84➂ <0.001
PDA/Q25.001 587 0.81 13 0.81c 22 0.96e 460 0.71f 5 0.14c,e,f <0.001 162 1.44➀,➁ 300 0.53➀,➂ 9 0.19➁,➂ <0.001
TOF/Q21.300 379 0.52 92 5.73a,b,c 47 2.05a,d,e 278 0.43b,d 26 0.71c,e <0.001 377 3.36➀,➁ 162 0.29➀,➂ 46 0.96➁,➂ <0.001
AVSD/Q21.200 294 0.41 35 2.18a,b,c 17 0.74a 257 0.40b 12 0.33c <0.001 174 1.55➀,➁ 347 0.61➀,➂ 10 0.21➁,➂ <0.001
PS/Q22.101 73 0.10 6 0.37 6 0.26 123 0.19 2 0.05 0.069 80 0.71➀,➁ 122 0.22➀ 3 0.06➂ <0.001
TR/Q22.801 43 0.06 6 0.37 4 0.17 91 0.14 8 0.22 0.074 80 0.71➀,➁ 79 0.14➀ 13 0.27➂ <0.001
PHT/Q25.751 18 0.02 3 0.19a 47 2.05a,d,e 69 0.11d 2 0.05e <0.001 82 0.73➀,➁ 39 0.07➀ 3 0.06➂ <0.001
COA/Q25.300 15 0.02 2 0.12 3 0.13 37 0.06 0 0.00 0.140 19 0.17➀ 0 0➀,➂ 2 0.04➂ <0.001
MR/Q23.300 12 0.02 2 0.12 2 0.09 32 0.05 0 0.00 0.231 41 0.37➀,➁ 28 0.05➀ 1 0.02➁ <0.001
AOS/Q23.001 9 0.01 1 0.06 1 0.04 27 0.04 4 0.11 0.316 71 0.63➀,➁ 20 0.04➀,➂ 15 0.31➁,➂ <0.001
TGA/Q20.302 7 0.01 1 0.06 1 0.04 21 0.03 0 0.00 0.626 37 0.33➀,➁ 0 0➀,➂ 1 0.02➁,➂ <0.001
Other 7 0.01 0 0.00 2 0.09 16 0.02 1 0.03 0.291 6 0.05➀ 7 0.01➀ 1 0.02 0.017
Total 6116 8.44 303 18.87a,b,c 294 12.84a,d,e 5344 8.24b,d,f 177 4.80c,e,f <0.001 1866 16.62➀,➁ 3944 6.99➀ 306 6.40➁ <0.001

ASD, atrial septal defect; VSD, ventricular septal defect; PFO, patent foramen ovale; PDA, patent ductus arteriosus; TOF, tetralogy of Fallot; AVSD, atrioventricular septal defect; PS, pulmonary valve stenosis; TR, tricuspid regurgitation; PHT, pulmonary hypertension; COA, coarctation of the aorta; MR, mitral regurgitation; AOS, aortic valve stenosis; TGA, transposition of great vessels; Other, classification is not clear. aA difference between the <1,500 g group and the 1,500–2,500 g group; bA difference between the <1,500 g group and the 2,500–4,000 g group; cA difference between the <1,500 g group and the ≥4,000 g group; dA difference between the 1,500–2,500 g group and the 2,500–4,000 g group; eA difference between the 1,500–2,500 g group and the ≥4,000 g group; fA difference between the 2,500–4,000 g group and the ≥4,000 g group; ➀A difference between the SGA group and the AGA group; ➁A difference between the SGA group and the LGA group; ➂A difference between the AGA group and the LGA group. The bold values in the tables represent statistically significant differences.