FIGURE 2.

MiR‐124‐3p interference efficiency and behavioral evaluation. (A) Agomir‐124‐3p, antagomir‐124‐3p, and NCs were injected into the lateral ventricle at a volume of 10 μl per side, and the SVZ tissue was dissected 3 days postinjection. At concentrations of 100, 200, and 400 pmol per side, the injected RNAs all led to significant changes in miR‐124‐3p expression, and 400 pmol RNAs was applied in the following experiments. ^⁎ p < 0.05, ^⁎⁎ p < 0.01, and ^⁎⁎⁎ p < 0.001 vs. the NC group. CCI rats then achieved double‐sided lateral ventricle injection of NC, agomir or antagomir on the first day after injury and were then evaluated on the basis of mNSS scores (B) and a rotarod test (C). The results were analyzed by nonparametric test (mNSS) or ANOVA (rotarod), and the performance of the TBI + antagomir group was found to be better than that of the TBI + agomir or TBI + NC group. No significant difference was found between the TBI + agomir and TBI + NC groups. The data are presented as the means ± SD. ^⁎ p < 0.05, ^⁎⁎ p < 0.01, and ^⁎⁎⁎ p < 0.001 vs. the TBI + NC group. n = 6/group