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NLRP3 inhibition attenuated the effects of PM2.5 on cell pyroptosis. (A, B) The expressions of GSDMD and GSDMD‐N in NC+OGD/R, NC+OGD/R+PM2.5, NLRP3‐KD1+OGD/R, and NLRP3‐KD1+OGD/R+PM2.5 groups (*p<0.05, **p<0.01, ***p<0.001 vs. NC+OGD/R; #p<0.05, ###p<0.001 vs. NLRP3‐KD1+OGD/R+PM2.5; n = 3). (C) The confocal immunofluorescence staining of DAPI and SYTOX was detected in the four groups in HMC‐3 cells. Scale bar = 20 μm
