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. 2022 May 19;13:880878. doi: 10.3389/fphar.2022.880878

FIGURE 12.

FIGURE 12

Model of HO-induced apoptosis of lung epithelial cells. HO causes an increase in NOX4 expression leading to increased mt ROS production resulting in lung epithelial cell apoptosis. This HO-induced mt ROS production and apoptosis was reduced by silencing NOX4 or mt ROS scavenging by MitoTEMPO.