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. 2022 May 19;13:880878. doi: 10.3389/fphar.2022.880878

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Copyright © 2022 Harijith, Basa, Ha, Thomas, Jafri, Fu, MacFarlane, Raffay, Natarajan and Sudhadevi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genetic Deletion of Nox4 in AT2 cells of mice reduced HALI. Nox4 ^fl/fl control mice and Nox4 ^−/− Spc-Cre mice induced with tamoxifen and were subjected to NO or HO for 66 h. (A) Representative H&E photomicrographs of lung tissue sections from Nox4 ^fl/fl and Nox4 ^−/− Spc-Cre mice exposed to NO or HO. Quantitative data of (B) ALI scores based on the infiltrating neutrophils, alveolar wall thickening and proteinaceous debris deposition (C) BAL protein and (D) cell counts were elevated in HO exposed control mice and were attenuated by epithelial deletion of Nox4. Scale bar = 100 µm. n = 6. ****p < 0.0001, ***p < 0.001, **p < 0.01 and *p < 0.05.