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Deletion of Nox4 reduced AT2 cell death induced by HALI. (A) Representative immunohistochemical TUNEL assay micrographs of lung tissues from Nox4 fl/fl and Nox4 −/− Spc-Cre mice exposed to NO or HO (B) The quantified data indicated a lower percentage of TUNEL-positive apoptotic cells in the hyperoxic Nox4 −/− Spc-Cre group. n = 6. ***p < 0.001, **p < 0.01 and *p < 0.05.
