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. 2022 May 19;13:880878. doi: 10.3389/fphar.2022.880878

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Copyright © 2022 Harijith, Basa, Ha, Thomas, Jafri, Fu, MacFarlane, Raffay, Natarajan and Sudhadevi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Deletion of Nox4 in AT2 cells prevented the sustained lung injury induced by HO. HO caused an increase in baseline (A) respiratory system resistance (Rrs), (B) respiratory system elastance (Ers), (C) tissue dampening/tissue resistance (G), (D) tissue elasticity (H) and a decrease in (E) dynamic compliance (Crs) following HO in control Nox4 ^fl/fl mice as measured by forced oscillatory maneuvers on a flexiVent commercial ventilator. These responses were reduced upon knocking out Nox4. n = 6. ****p < 0.0001, ***p < 0.001, **p < 0.01 and *p < 0.05.