Table 2.
Baseline factors associated with UDCA response.
| Univariate analyses | Multivariate analyses | |||
|---|---|---|---|---|
| OR (95% CI OR) | p values | OR (95% OR) | p values | |
| Sex (male) | 0.848 (0.305~2.361) | 0.753 | ||
| Age (years) | 1.046 (1.012~1.082) | 0.008 | 1.039 (0.995~1.084) | 0.083 |
| AMA (diluted titer)* | 1.001 (1.00~1.001) | 0.14 | ||
| ANA (diluted titer)* | 1.00 (0.99~1.000) | 0.44 | ||
| AST(U/L) | 0.997 (0.991~1.002) | 0.228 | ||
| ALT(U/L) | 1.00 (0.996~1.003) | 0.808 | ||
| Alk-p (U/L) | 0.993 (0.990~0.996) | <0.001 | 0.995 (0.992~0.998) | 0.002 |
| γ-GT (U/L) | 1.00 (0.998~1.001) | 0.515 | ||
| Total bilirubin (mg/dL) | 0.625 (0.446~0.875) | 0.006 | 0.767 (0.568~1.034) | 0.082 |
| Albumin (g/dL) | 1.798 (0.785~4.119) | 0.165 | ||
| eGFR (ml/min/1.73m2) | 0.986 (0.965~1.007) | 0.2 | ||
| Platelet (K/uL) | 1.001 (0.965~1.007) | 0.762 | ||
| AFP (ng/mL) | 1.037 (0.856~1.255) | 0.713 | ||
| Liver cirrhosis, (yes/no) | 0.325 (0.141~0.750) | 0.008 | 0.28 (0.096~0.819) | 0.02 |
UDCA, ursodeoxycholic acid; OR, odds ratio; 95% CI, 95% confidence interval; AMA, antimitochondrial antibody; ANA, antinuclear antibody; AST, aspartate transaminase; ALT, alanine aminotransferase; Alk-p, alkaline phosphatase; γ-GT, gamma-glutamyltransferase. eGFR, estimated glomerular filtration rate; AFP, alpha fetoprotein. *, The diluted titer “1, X” was presented as “X”. For example, the diluted titers such as 1,40, 1,80, 1,160, 1,320, 1,640, 1,1280 were presented as 40, 80, 160, 320, 640 and 1280, respectively.