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. 2022 May 19;10:840066. doi: 10.3389/fcell.2022.840066

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Copyright © 2022 Edgar, Park, Crawshaw, Osborne, Eichmann and Bernabeu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The idealised capillary plexus domain. Endothelial agents were confined to the surfaces of lumen segments, the diameter of which was determined by the number of occupant cells (upper inset). Pressure was prescribed at the inlet and outlet as to create forward flow (postive) along the +x direction. Cells align their polarity and migrate against the direction of flow (lower inset) At flow-covergent bifurcations, cells in the parent branch split evenly amongst the two child branches. At flow-divergent bifurcations, cells in the two child branches combine at the parent branch.