FIGURE 4.

Force transmission regulates EC migration dynamics. (A) Histrogram of migration speeds amongst the cell population across all simulations were centred at the mean migration speed, $\overline{v}$ . In simulations without cohesion ( $W_{\text{pull}}^{\ast }=0$ ), increasing extrusion increased the spread of migration speeds amongst cells. (B) Similarly, in simulations with constant extrustion ( $W_{\text{push}}^{\ast }=3$ ) increased cohesion flattened the distribution of migration speeds amongst cells further (C) Simulations with low extrusion (i.e., $W_{\text{push}}^{\ast }<1$ ). resulted in near uniform migration speed of $\overline{v}$ amongst ECs throughout the plexus (yellow). (D) Increased extrusion resulted in more cells moving at speeds faster (green) and slower (red) than $\overline{v}$ . (E) Adding cohesion further increased heterogenity in migration speeds amongst cells throughout the plexus. (F) The cell trajectory distance measures the total distance travelled by cells during the simulation. Interestingly, in simulations without cohesion cells travelled further with increased extrusion as seen by a shift to the right in the distributions of cell trajectory distance. (G) Similarly, increased cohesion caused ECs to travel further as seen in similar shifts to the right in the distributions of cell trajectory distance.