Table 3.
Univariate and multivariate Cox proportional hazards analysis of KRT8 expression and DSS for patients with LUAD in the TCGA cohort.
| Characteristics | Total (N) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P-value | Hazard ratio (95% CI) | P-value | ||
| T stage (T2 & T3 & T4 vs. T1) | 488 | 1.850 (1.195–2.865) | 0.006 | 1.503 (0.810–2.789) | 0.197 |
| N stage (N1 & N2 & N3 vs. N0) | 475 | 2.703 (1.873–3.900) | <0.001 | 1.910 (1.105–3.304) | 0.021 |
| M stage (M1 vs. M0) | 344 | 2.455 (1.269–4.749) | 0.008 | 1.114 (0.413–3.007) | 0.831 |
| Gender (Male vs. Female) | 491 | 0.989 (0.687–1.424) | 0.954 | ||
| Race (White vs. Asian & Black or African American) | 445 | 1.151 (0.667–1.985) | 0.614 | ||
| Smoker (Yes vs. No) | 477 | 1.040 (0.602–1.796) | 0.889 | ||
| Pathologic stage (Stage III & Stage IV vs. Stage I & Stage II) | 483 | 2.436 (1.645–3.605) | <0.001 | 1.382 (0.697–2.744) | 0.354 |
| Age (>65 vs. ≤65) | 481 | 1.013 (0.701–1.464) | 0.944 | ||
| Residual tumor (R1 & R2 vs. R0) | 331 | 4.743 (2.352–9.566) | <0.001 | 4.043 (1.542–10.602) | 0.005 |
| KRT8 (High vs. Low) | 491 | 1.625 (1.123–2.353) | 0.010 | 1.006 (0.603–1.679) | 0.982 |
CI, confidence interval; HR, hazard ratio.