TABLE 1.
Demographic and clinical characteristics by diagnostic group
| NC (n = 235) | MCI (n = 181) | AD dementia (n = 153) | ||
|---|---|---|---|---|
| Demographic variables | ||||
| Age | 72.38 (7.69) | 74.96 (7.25) | 76.82 (8.13) | |
| Sex (male: female) | 37:63 | 42:58 | 56:44 | |
| Race (non-Hispanic White: non-White) | 90:10 | 75:25 | 92:8 | |
| Years of education | 16.56 (2.54) | 15.52 (2.77) | 14.95 (2.95) | |
| Genetic | ||||
| APOE ε4 allele status (yes: no) | 33:67 | 33:67 | 58:42 | |
| Neuropsychological measures | ||||
| Animal Fluency | 22.08 (5.27) | 16.98 (5.13) | 10.45 (5.37) | |
| BNT | 28.23 (1.65) | 25.31 (4.49) | 20.27 (7.23) | |
| DSF | 6.99 (0.93) | 6.40 (1.03) | 6.13 (1.21) | |
| DSB | 5.30 (1.23) | 4.64 (1.25) | 3.61 (1.42) | |
| LM-II | 14.70 (3.74) | 11.02 (4.66) | 2.34 (3.44) | |
| MMSE | 29.39 (0.91) | 28.20 (1.68) | 21.12 (6.21) | |
| NAB Trials 1–3 | 23.69 (4.53) | 18.21 (5.01) | 9.94 (4.91) | |
| NAB SD | 8.39 (2.36) | 5.32 (2.59) | 1.24 (1.75) | |
| NAB LD | 8.41 (2.41) | 4.91 (2.79) | 0.72 (1.46) | |
| TMT-A | 28.78 (8.80) | 36.97 (18.03) | 63.08 (38.88) | |
| TMT-B | 69.50 (28.47) | 127.76 (78.14) | 223.30 (88.42) | |
| Vegetable Fluency | 15.71 (3.97) | 12.93 (3.89) | 6.64 (3.98) | |
| Functional | ||||
| CDR Sum of Boxes | 0.07 (0.26) | 0.37 (0.64) | 6.53 (4.27) | |
| FAQ | 0.23 (1.99) | 0.65 (1.89) | 14.27 (9.74) | |
| Biomarkers | ||||
| NfL | 15.43 (10.51) | 17.61 (9.89) | 26.57 (17.45) | |
| P-tau181 | 16.05 (11.07) | 18.10 (10.01) | 25.92 (15.62) | |
| T-tau | 3.20 (2.73) | 3.29 (2.39) | 3.70 (2.99) |
Note. Values reflect mean or proportion, with standard deviation in parentheses.
Abbreviations: AD, Alzheimer’s disease; BNT, Boston Naming Test; CDR, Clinical Dementia Rating; DSF & DSB, Digit Span Forward and Backward; FAQ, Functional Activities Questionnaire; LM-II, Logical Memory Delayed Recall; MCI, mild cognitive impairment; MMSE, Mini-Mental State Examination; NAB SD & LD, Neuropsychological Assessment Battery List Learning Test, Short and Long Delay; NC, normal control; NfL, neurofilament light; P-tau181, hyperphosphorylated tau; TMT-A & B, Trail Making Test; Parts A and B; T-tau, total tau.