TABLE 2.
Multinomial model contrasting the normal control group versus each of the other groups (N = 569)
| NC vs. | β z | COR | 95% CI | Wald Z | P | |
|---|---|---|---|---|---|---|
| (Intercept) | MCI | 0.067 | 1.07 | (0.06, 17.27) | 0.047 | 0.962 |
| AD dementia | 1.811 | 6.12 | (0.16, 205.35) | 1.115 | 0.265 | |
| P-tau181 | MCI | 0.126 | 1.13 | (0.89, 1.44) | 1.015 | 0.310 |
| AD dementia | 0.385 | 1.47 | (1.06, 2.08) | 2.650 | 0.008** | |
| T-tau | MCI | 0.056 | 1.06 | (0.83, 1.35) | 0.491 | 0.624 |
| AD dementia | 0.184 | 1.20 | (0.91, 1.58) | 1.402 | 0.161 | |
| NfL | MCI | 0.220 | 1.25 | (0.93, 1.67) | 1.578 | 0.115 |
| AD dementia | 0.929 | 2.53 | (1.71, 3.65) | 5.573 | <0.001*** | |
| Age | MCI | 0.024 | 1.02 | (0.99, 1.06) | 1.491 | 0.136 |
| AD dementia | 0.018 | 1.02 | (0.98, 1.06) | 0.979 | 0.327 | |
| Race | MCI | 1.067 | 2.91 | (1.51, 5.52) | 3.578 | <0.001*** |
| AD dementia | −0.300 | 0.74 | (0.27, 1.83) | −0.696 | 0.487 | |
| Sex | MCI | −0.394 | 0.67 | (0.43, 1.05) | −1.809 | 0.070 |
| AD dementia | −1.072 | 0.34 | (0.21, 0.59) | −4.171 | <0.001*** | |
| Years of education | MCI | −0.124 | 0.88 | (0.82, 0.96) | −3.060 | 0.002** |
| AD dementia | −0.232 | 0.79 | (0.72, 0.88) | −4.897 | <0.001*** | |
| APOE ε4 allele status | MCI | 0.037 | 1.04 | (0.67, 1.64) | 0.162 | 0.871 |
| AD dementia | 1.125 | 3.08 | (1.80, 5.12) | 4.394 | <0.001*** |
Abbreviations: AD, Alzheimer’s disease; APOE, apolipoprotein E; CI, confidence interval; COR, conditional odds ratio; MCI, mild cognitive impairment; NC, normal control; NfL, neurofilament light; P-tau181, hyperphosphorylated tau; T-tau, Total tau.