Table 2.
Statistical comparison of nicotine pharmacokinetic parameters
| BIDI® Stick Arctic | BIDI® Stick Classic | BIDI® Stick Regal | BIDI® Stick Solar | BIDI® Stick Winter | BIDI® Stick Zest | JUUL VT | |
|---|---|---|---|---|---|---|---|
| Cmax 0–120 LS Means [90% CI]a | |||||||
| BIDI Stick® Classic ENDS | 0.89 [0.71,1.12] | – | – | – | – | – | – |
| BIDI Stick® Regal ENDS | 1.01 [0.80,1.27] | 1.13 [0.90,1.43] | – | – | – | – | – |
| BIDI Stick® Solar ENDS | 1.07 [0.85,1.35] | 1.20 [0.95,1.51] | 1.06 [0.84,1.33] | – | – | – | – |
| BIDI Stick® Winter ENDS | 1.05 [0.83,1.33] | 1.18 [0.93,1.49] | 1.04 [0.82,1.31] | 0.98 [0.78,1.24] | – | – | – |
| BIDI Stick® Zest ENDS | 0.94 [0.75,1.19] | 1.06 [0.84,1.33] | 0.93 [0.74,1.18] | 0.88 [0.70,1.11] | 0.89 [0.71,1.13] | – | – |
| JUUL VT ENDS | 2.44 [1.93,3.08] | 2.74 [2.17,3.45] | 2.42 [1.91,3.05] | 2.28 [1.81,2.88] | 2.32 [1.84,2.93] | 2.59 [2.06,3.27] | – |
| UB cigarette | 1.00 [0.72,1.38] | 1.12 [0.81,1.55] | 0.99 [0.71,1.37] | 0.93 [0.67,1.29] | 0.95 [0.68,1.32] | 1.06 [0.77,1.47] | 0.41 [0.30,0.57] |
| AUC0-120 LS Means [90% CI]a | |||||||
| BIDI Stick® Classic ENDS | 0.83 [0.63,1.09] | – | – | – | – | – | – |
| BIDI Stick® Regal ENDS | 0.97 [0.73,1.28] | 1.17 [0.88,1.55] | – | – | – | – | – |
| BIDI Stick® Solar ENDS | 0.94 [0.71,1.24] | 1.13 [0.85,1.5] | 0.97 [0.73,1.28] | – | – | – | – |
| BIDI Stick® Winter ENDS | 0.99 [0.75,1.31] | 1.20 [0.91,1.59] | 1.02 [0.77,1.36] | 1.06 [0.8,1.41] | – | – | – |
| BIDI Stick® Zest ENDS | 0.84 [0.63,1.11] | 1.01 [0.76,1.34] | 0.86 [0.65,1.14] | 0.89 [0.67,1.18] | 0.84 [0.64,1.11] | – | – |
| JUUL VT ENDS | 2.93 [2.21,3.88] | 3.54 [2.68,4.69] | 3.03 [2.29,4.01] | 3.13 [2.37,4.15] | 2.95 [2.23,3.91] | 3.51 [2.65,4.64] | – |
| UB cigarette | 0.70 [0.47,1.04] | 0.84 [0.57,1.25] | 0.72 [0.49,1.07] | 0.75 [0.5,1.11] | 0.70 [0.48,1.04] | 0.84 [0.56,1.24] | 0.24 [0.16,0.35] |
| Tmax 0–120 Odds Ratios [90% CI]b | |||||||
| BIDI Stick® Classic ENDS | 0.79 [0.25,2.42] | – | – | – | – | – | – |
| BIDI Stick® Regal ENDS | 0.70 [0.23,2.16] | 0.89 [0.29,2.76] | – | – | – | – | – |
| BIDI Stick® Solar ENDS | 0.84 [0.27,2.58] | 1.07 [0.35,3.30] | 1.20 [0.39,3.71] | – | – | – | – |
| BIDI Stick® Winter ENDS | 0.65 [0.21,2.02] | 0.83 [0.27,2.58] | 0.93 [0.30,2.90] | 0.78 [0.25,2.41] | – | – | – |
| BIDI Stick® Zest ENDS | 1.40 [0.46,4.29] | 1.79 [0.58,5.49] | 2.01 [0.65,6.19] | 1.67 [0.54,5.13] | 2.15 [0.70,6.65] | – | – |
| JUUL VT ENDS | 0.59 [0.19,1.82] | 0.75 [0.24,2.33] | 0.84 [0.27,2.62] | 0.70 [0.23,2.18] | 0.90 [0.29,2.81] | 0.42 [0.13,1.30] | – |
| UB cigarette | 1.08 [0.36,3.27] | 1.38 [0.45,4.19] | 1.54 [0.51,4.71] | 1.29 [0.42,3.91] | 1.66 [0.54,5.06] | 0.77 [0.26,2.32] | 1.84 [0.60,5.65] |
Statistical significance is concluded if the CIs do not contain 1.00
UB usual brand; LS least square; CI confidence interval; and VT Virginia Tobacco. Values which were significantly different are in bold type
N = 17–18 in each case
aBack-transformed (exponentiated) linear mixed model parameter estimates used to create 90% CI ratios of geometric least-squares means between study products
bOdds ratios 90% CIs