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Schematic diagram of cytokine/growth factor-loaded polysaccharide hydrogel-metal scaffold composite and its role in promoting bone regeneration. ECM-inspired HQ hydrogel was complexed with Ti6Al4V scaffold, which significantly promoted in vivo regeneration of femur defect by IL-4-mediated immune-modulation and BMP-2-induced osteogenesis in the local tissue microenvironment.
