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. 2022 Feb 22;9:rbac009. doi: 10.1093/rb/rbac009

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© The Author(s) 2022. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 9. — Delivery of aPDL-1 by ROS-responsive hydrogel for immunotherapy of tumour. (a) Schematic of combination chemoimmunotherapy using a ROS-degradable hydrogel scaffold to deliver GEM and aPDL1 into the tumour microenvironment. (b) In vivo bioluminescence imaging of the B16F10 tumour in control and treated groups. (c–d) Absolute numbers of the CD8⁺ (c) and CD4⁺ T cells (d) per gram of the tumour upon various treatments. (e–f) Ratios of the tumour-infiltrating CD8⁺ T cells (e) and CD4⁺ T cells (f) to Tregs in the tumours upon various treatments. Adapted with permission from Ref. [176].