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. 2022 May 19;13:861105. doi: 10.3389/fphar.2022.861105

FIGURE 4.

FIGURE 4

Protection of oroxylin A on endotoxemia mice. (A) Survival rates of LPS-induced endotoxemia mice with administration of oroxylin A and chrysin. (B) Body weight of LPS-induced endotoxemia mice with administration of oroxylin A and chrysin. (C) Inhibitory response of pro-inflammatory cytokine IL-6, IL-1β, and TNF-α in LPS-induced endotoxemia mice plasma by different doses of oroxylin A (n = 3). Oroxylin A and chrysin (3.0 mg/kg) were injected to mice every day after LPS challenge (30 mg/kg, iv). The first-time treatment was 30 min prior to the injection of LPS. (D) Survival rates of CLP-induced endotoxemia mice with administration of oroxylin A and dexamethasone. (E) Body weight of CLP-induced endotoxemia mice with administration of oroxylin A and dexamethasone. Oroxylin A and dexamethasone (3.0 mg/kg) were injected 30 min before mice subjected to CLP. Drugs were administrated every day. Data are presented as mean ± SD. ##p < 0.01 vs. control, *p < 0.05 vs. model, **p < 0.01 vs. model.