Table 2.
Demographic and clinical comparison between cohorts.
|
Derivation N = 642 |
Validation N = 381 |
P -value | |
|---|---|---|---|
| Age | 60.9 ± 16.1 | 61.8 ± 15.9 | 0.3808 |
| Sex– no. (%) | 375 (58.4%) | 208 (54.6%) | 0.2597 |
| Race– no. (%) | |||
| White | 424 (66.0%) | 281 (73.8%) | 0.0122 |
| Black | 168 (26.2%) | 77 (20.2%) | 0.0372 |
| Other | 50 (7.8%) | 23 (6.0%) | 0.3542 |
| Infectious source– no. (%) | |||
| Pneumonia | 200 (31.2%) | 123 (32.3%) | 0.7591 |
| Intraabdominal infection | 93 (14.5%) | 53 (13.9%) | 0.8714 |
| Urosepsis | 138 (21.5%) | 81 (21.3%) | 0.9921 |
| Skin or soft tissue infection | 48 (7.5%) | 27 (7.1%) | 0.9145 |
| CNS | 6 (0.9%) | 2 (0.5%) | 0.7248 |
| Endocarditis | 0 (0.0%) | 5 (1.3%) | 0.0144 |
| Catheter-related infection | 21 (3.3%) | 9 (2.4%) | 0.5213 |
| Unknown | 78 (12.1%) | 45 (11.8%) | 0.9509 |
| Other | 44 (6.9%) | 24 (6.3%) | 0.8303 |
| None | 14 (2.2%) | 12 (3.1%) | 0.4554 |
| Blood culture positive–no. (%) | 204 (31.8%) | 115 (30.2%) | 0.6444 |
| Illness severity | |||
| APACHE II | 21.7 ± 7.9 | 20.3 ± 7.5 | 0.0044 |
| APACHE III | 63.6 ± 23.5 | 63.3 ± 20.8 | 0.8725 |
| Charleson | 2.6 ± 2.6 | 2.7 ± 2.6 | 0.7043 |
| SOFA | 2.0 ± 1.6 | 2.4 ± 1.6 | 0 |
| SOFA cardiac | 0.9 ± 1.3 | 0.7 ± 1.1 | 0.0013 |
| SOFA CNS | 0.6 ± 1.0 | 0.5 ± 1.0 | 0.103 |
| SOFA coag | 0.7 ± 1.0 | 0.6 ± 0.9 | 0.1339 |
| SOFA liver | 1.5 ± 1.3 | 1.3 ± 1.2 | 0.0033 |
| SOFA renal | 1.8 ± 1.2 | 1.8 ± 1.2 | 0.6292 |
| SOFA respiratory | 7.5 ± 3.6 | 7.3 ± 3.6 | 0.2426 |
| Physiologic variables | |||
| SBP (mmHg) | 98.9 ± 30.2 | 101.3 ± 26.3 | 0.1856 |
| Heart Rate | 112.0 ± 24.0 | 109.6 ± 23.7 | 0.1234 |
| Temperature (Celsius) | 37.4 ± 1.6 | 37.3 ± 1.4 | 0.4886 |
| Respiratory rate | 22.9 ± 7.2 | 22.0 ± 6.1 | 0.0392 |
| Total bilirubin | 1.5 ± 2.0 | 1.5 ± 2.4 | 0.7136 |
| Lactate | 3.4 ± 3.3 | 2.4 ± 1.9 | 0.0003 |
| Mortality–no. (%) | |||
| 14 days | 130 (20.2%) | 61 (16.0%) | 0.1098 |
| 28 days | 154 (24.0%) | 80 (21.0%) | 0.3059 |
| 60 days | 182 (28.3%) | 99 (26.0%) | 0.4552 |
| 1 year | 234 (36.4%) | 135 (35.4%) | 0.7951 |
| Multiorgan failure, baseline | 384 (59.8%) | 216 (56.7%) | 0.3607 |
| New organ failure–no. (%) | |||
| Cardiac | 401 (62.5%) | 247 (64.8%) | 0.4884 |
| Renal | 30 (4.7%) | 9 (2.4%) | 0.0897 |
| Respiratory | 254 (39.6%) | 122 (32.0%) | 0.0187 |
| Hosp LOS | 11.7 ± 10.9 | 11.2 ± 10.4 | 0.4804 |
| ICU LOS | 4.9 ± 6.0 | 5.1 ± 7.1 | 0.6555 |
| Number of SAEs | 15 (2.3%) | 10 (2.6%) | 0.2571 |
| Subject disposition category– no. (%) | |||
| Home | 323 (50.3%) | 200 (52.5%) | 0.5417 |
| SNF | 119 (18.5%) | 62 (16.3%) | 0.4053 |
| Dead | 146 (22.7%) | 77 (20.2%) | 0.3844 |