Table 4.
Demographic and clinical characteristics of phenotypes in derivation cohort.
|
L1 N = 178 (28%) |
L2 N = 135 (21%) |
M N = 102 (16%) |
H1 N = 125 (19%) |
H2 N = 102 (16%) |
P –value | |
|---|---|---|---|---|---|---|
| Age | 58.8 ± 15.6 | 58.7 ± 15.6 | 65.6 ± 16.5 | 65.9 ± 16.5 | 56.7 ± 14.4 | <0.0001 |
| Sex–no. (%) | 103 (57.9%) | 97 (71.9%) | 52 (51.0%) | 62 (49.6%) | 61 (59.8%) | 0.0025 |
| Race–no. (%) | ||||||
| White | 121 (68.0%) | 81 (60.0%) | 73 (71.6%) | 81 (64.8%) | 68 (66.7%) | 0.4077 |
| Black | 40 (22.5%) | 43 (31.9%) | 25 (24.5%) | 34 (27.2%) | 26 (25.5%) | 0.4403 |
| Other | 17 (9.6%) | 11 (8.1%) | 4 (3.9%) | 10 (8.0%) | 8 (7.8%) | 0.5703 |
| Infectious source– no. (%) | ||||||
| Pneumonia | 60 (33.7%) | 30 (22.2%) | 43 (42.2%) | 47 (37.6%) | 20 (19.6%) | 0.0005 |
| Intraabdominal infection | 21 (11.8%) | 26 (19.3%) | 7 (6.9%) | 16 (12.8%) | 23 (22.5%) | 0.0075 |
| Urosepsis | 48 (27.0%) | 25 (18.5%) | 22 (21.6%) | 25 (20.0%) | 18 (17.6%) | 0.2948 |
| Skin or soft tissue infection | 7 (3.9%) | 15 (11.1%) | 6 (5.9%) | 9 (7.2%) | 11 (10.8%) | 0.0987 |
| CNS | 2 (1.1%) | 1 (0.7%) | 2 (2.0%) | 1 (0.8%) | 0 (0.0%) | 0.6862 |
| Endocarditis | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | N/A |
| Catheter related infection | 7 (3.9%) | 4 (3.0%) | 1 (1.0%) | 4 (3.2%) | 5 (4.9%) | 0.5853 |
| Unknown | 18 (10.1%) | 14 (10.4%) | 16 (15.7%) | 15 (12.0%) | 15 (14.7%) | 0.5722 |
| Other | 11 (6.2%) | 14 (10.4%) | 3 (2.9%) | 6 (4.8%) | 10 (9.8%) | 0.116 |
| None | 4 (2.2%) | 6 (4.4%) | 2 (2.0%) | 2 (1.6%) | 0 (0.0%) | 0.2193 |
| Blood culture positive– no. (%) | 45 (25.3%) | 35 (25.9%) | 38 (37.3%) | 37 (29.6%) | 49 (48.0%) | 0.0006 |
| Illness severity | ||||||
| APACHEII | 17.6 ± 5.4 | 17.7 ± 6.2 | 24.1 ± 7.9 | 28.2 ± 8.1 | 23.8 ± 6.2 | <0.0001 |
| APACHEIII | 55.9 ± 16.0 | 48.5 ± 18.4 | 71.0 ± 26.3 | 78.4 ± 24.3 | 71.2 ± 19.7 | <0.0001 |
| Charleson | 2.4 ± 2.4 | 2.2 ± 2.5 | 2.3 ± 2.2 | 3.2 ± 2.7 | 3.2 ± 3.0 | 0.0021 |
| SOFA | 5.8 ± 2.6 | 5.4 ± 2.8 | 8.0 ± 3.2 | 10.2 ± 3.8 | 9.6 ± 3.1 | <0.0001 |
| SOFA cardiac | 2.2 ± 1.4 | 0.9 ± 1.2 | 1.5 ± 1.6 | 2.8 ± 1.4 | 2.2 ± 1.5 | <0.0001 |
| SOFA CNS | 0.1 ± 0.4 | 0.2 ± 0.6 | 2.3 ± 1.2 | 2.2 ± 1.3 | 0.4 ± 0.8 | <0.0001 |
| SOFA coag | 0.5 ± 0.9 | 0.5 ± 1.0 | 0.3 ± 0.6 | 0.5 ± 0.9 | 1.4 ± 1.2 | <0.0001 |
| SOFA liver | 0.4 ± 0.8 | 0.7 ± 1.0 | 0.4 ± 0.6 | 0.5 ± 0.8 | 1.5 ± 1.2 | <0.0001 |
| SOFA renal | 1.2 ± 1.2 | 1.5 ± 1.3 | 1.2 ± 1.2 | 1.9 ± 1.3 | 2.2 ± 1.1 | <0.0001 |
| SOFA respiratory | 1.4 ± 1.0 | 1.5 ± 1.1 | 2.4 ± 1.2 | 2.2 ± 1.2 | 1.9 ± 1.1 | <0.0001 |
| Physiologic variables | ||||||
| SBP | 86.9 ± 18.5 | 114.2 ± 35.2 | 117.4 ± 34.7 | 91.7 ± 24.1 | 90.1 ± 23.9 | <0.0001 |
| HR | 109.2 ± 22.6 | 112.6 ± 23.1 | 121.4 ± 22.8 | 104.9 ± 26.1 | 115.3 ± 22.6 | <0.0001 |
| Temp | 37.6 ± 1.3 | 37.4 ± 1.4 | 37.9 ± 1.8 | 36.9 ± 2.1 | 37.1 ± 1.5 | <0.0001 |
| RR | 21.5 ± 5.2 | 23.2 ± 7.0 | 24.0 ± 9.1 | 23.4 ± 8.5 | 23.0 ± 6.2 | 0.0289 |
| Tbili | 1.1 ± 1.3 | 1.5 ± 1.9 | 1.0 ± 0.5 | 0.9 ± 0.5 | 3.5 ± 3.4 | <0.0001 |
| Lactate | 1.9 ± 1.3 | 3.1 ± 2.1 | 3.6 ± 3.0 | 3.3 ± 3.5 | 6.0 ± 4.7 | <0.0001 |
| Mortality–no. (%) | ||||||
| 14 days | 14 (7.9%) | 17 (12.6%) | 26 (25.5%) | 36 (28.8%) | 37 (36.3%) | <0.0001 |
| 28 days | 17 (9.6%) | 19 (14.1%) | 33 (32.4%) | 43 (34.4%) | 42 (41.2%) | <0.0001 |
| 60 days | 26 (14.6%) | 23 (17.0%) | 35 (34.3%) | 53 (42.4%) | 45 (44.1%) | <0.0001 |
| 1 year | 40 (22.5%) | 31 (23.0%) | 40 (39.2%) | 69 (55.2%) | 54 (52.9%) | <0.0001 |
| Multiorgan failure, baseline | 66 (37.1%) | 55 (40.7%) | 75 (73.5%) | 100 (80.0%) | 88 (86.3%) | <0.0001 |
| New organ failure–no. (%) | ||||||
| Cardiac | 125 (70.2%) | 46 (34.1%) | 48 (47.1%) | 102 (81.6%) | 80 (78.4%) | <0.0001 |
| Renal | 1 (0.6%) | 4 (3.0%) | 2 (2.0%) | 9 (7.2%) | 14 (13.7%) | <0.0001 |
| Respiratory | 35 (19.7%) | 34 (25.2%) | 60 (58.8%) | 74 (59.2%) | 51 (50.0%) | <0.0001 |
| Hosp LOS | 10.1 ± 8.9 | 11.5 ± 10.6 | 11.1 ± 9.8 | 13.0 ± 11.5 | 13.5 ± 14.2 | 0.076 |
| ICU LOS | 3.8 ± 3.2 | 3.7 ± 4.8 | 5.6 ± 7.3 | 5.9 ± 5.8 | 6.7 ± 8.7 | <0.0001 |
| Number of SAEs | 4 (2.2%) | 3 (2.2%) | 4 (3.9%) | 2 (1.6%) | 2 (2.0%) | 0.0502 |
| Subject Disposition Category–no. (%) | ||||||
| Home | 114 (64.0%) | 87 (64.4%) | 42 (41.2%) | 34 (27.2%) | 46 (45.1%) | <0.0001 |
| SNF | 27 (15.2%) | 23 (17.0%) | 22 (21.6%) | 35 (28.0%) | 12 (11.8%) | 0.013 |
| Dead | 16 (9.0%) | 17 (12.6%) | 30 (29.4%) | 43 (34.4%) | 40 (39.2%) | <0.0001 |