TABLE 4.
Effect of IL-6 on action potential and IKr of guinea pig left ventricular myocytes.
| APD90 (ms) | APA (mV) | IKr (pA/pF) | |
| Control | 430 ± 13.0 (n = 18) | 136 ± 0.9 (n = 18) | 0.79 ± 0.03 (n = 10) |
| IL-6 | 509 ± 13.0** (n = 11) | 133 ± 1.0 (n = 11) | 0.68 ± 0.03* (n = 9) |
APD90, action potential duration at 90%; APA, action potential amplitude; IKr, rapid delayed rectifier current.
IL-6 was used at the concentration of 200 μg/L.
All values are expressed as mean ± SE. The number of experiments performed is indicated by “n = .”
The unpaired t-test was used to compare data regarding IL-6 for AP, APA, and IKr with control. *P < 0.05, **P < 0.01 vs. control.