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. 2022 Jun 1;10(6):e004440. doi: 10.1136/jitc-2021-004440

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Stromal CD8⁺ effector T cells are associated with better outcome after ICI in NSCLC cases with PD-L1 expressing tumors. (A) TILs density by compartment based on PD-L1 status. (B–E) Forest plots showing the PFS and OS Hazard ratios calculated for the continuous levels of each TIL marker using a Cox univariate model in PD-L1 positive (B and C) and negative cases (D and E). (F–I) Kaplan-Meier graphical analysis of the PFS and OS of cases in the cohort stratified by high (top 15% of scores) and low (bottom 85% of scores) density of stromal CD8⁺ T cells in the PD-L1 positive and negative group. ICI, immune checkpoint blockers; NSCLC, non-small cell lung cancer; OS, overall survival; PD-L1, programmed death ligand-1; PFS, progression-free survival; TIL, tumor infiltrating lymphocyte.