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. 2022 Jun 1;10(6):e004440. doi: 10.1136/jitc-2021-004440

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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High spatial immune heterogeneity is associated with worse survival after ICI in NSCLC. (A) Graphical representation of cases with low RQI (left) and high RQI (right) immune heterogeneity scores. (B) Violin plot showing the RQI in individual cell subsets obtained from NSCLCs in the cohort. (C) Bar Plot showing the distribution of the for the integrated RQI scores calculated from all cell subsets in the cohort cases. (D–E) Survival analysis of progression-free survival and overall survival of NSCLC cases stratified by the mean integrated RQI of the cohort. (F–G) Survival analysis of cases stratified by the mean integrated RQI based on the PD-L1 status. NSCLC, non-small lung cancer; PD-L1, programmed death ligand-1; RQI, Rao’s Q Index.