Table 3.
HR of out-of-hospital cardiac arrest following treatment with non-steroidal anti-inflammatory drugs (NSAIDs) in patients with rheumatoid arthritis
| Cases (n=512) |
Controls (n=3867) |
Crude HR | Adjusted HR | |
| No use of NSAIDs | 402 (78.52) | 2994 (77.42) | 1.0 (reference) | 1.0 (reference) |
| Use of NSAIDs | 110 (21.48) | 873 (22.58) | 0.93 (0.74 to 1.17) | 1.03 (0.82 to 1.30) |
| Individual NSAID | ||||
| Diclofenac | 10 (1.95) | 99 (2.56) | 0.75 (0.39 to 1.46) | 0.84 (0.43 to 1.63) |
| Ibuprofen | 39 (7.62) | 294 (7.60) | 0.98 (0.69 to 1.39) | 1.06 (0.74 to 1.51) |
| Naproxen | 5 (0.95) | 34 (0.88) | 1.09 (0.42 to 2.81) | 1.17 (0.44 to 3.08) |
| Celecoxib | 7 (1.37) | 70 (1.81) | 0.74 (0.40 to 1.63) | 0.85 (0.38 to 1.90) |
| Rofecoxib | 8 (1.56) | 38 (0.98) | 1.53 (0.71 to 3.31) | 1.80 (0.82 to 3.94) |
| Others | 38 (7.42) | 324 (8.38) | 0.87 (0.61 to 1.23) | 0.96 (0.67 to 1.38) |
Numbers in table are number (%) unless indicated otherwise. HR adjusted for age, sex, cardiovascular comorbidities and the use of QT-prolonging drugs. Not included users of multiple NSAIDs.