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Intracellular signaling and metabolic pathways activated into RA anti-inflammatory M2 macrophages. Metabolic pathways activated in M2 macrophages that contribute to their anti-inflammatory role in RA. NFkB, nuclear factor-kB; SIRT1, sirtuin-1; AMPK, adenosine monophosphate-activated protein kinase; IL-10, interleukine-10; IL-12, interleukine-12; TGFβ1, transforming growth factor-β1; NO, nitric oxide; CD206, mannose receptor-1; UDP-GlcNAc, uridine diphosphate N-acetylglucosamine.
