Table 1. Patient Characteristics in the Internal Cohort.
| Variable | Entire cohort (n = 965) | |||||
|---|---|---|---|---|---|---|
| KRAS variant | Wild type | |||||
| Train (n = 302) | Test (n = 84) | Entire (n = 386) | Train (n = 474) | Test (n = 105) | Entire (n = 579) | |
| Numerical variables, median (IQR) | ||||||
| Age, y | 58.7 (49.0-68.4) | 55.9 (49.5-68.9) | 58.3 (49.0-68.7) | 59.0 (50.0-67.3) | 54.1 (47.4-66.0) | 58.2 (49.1-67.3) |
| No. of CRLM | 3.0 (1-4) | 2.0 (1-3) | 2.0 (1-4) | 2.0 (1-5) | 2.0 (1-5) | 2.0 (1-5) |
| Diameter of largest CRLM, median (IQR), cm | 2.5 (1.6-4.0) | 2.5 (1.6-4.0) | 2.5 (1.6-4.0) | 2.5 (1.6-4.0) | 2.6 (1.8-3.7) | 2.5 (1.6-4.0) |
| Margin width, mm | 3.0 (1-8) | 2.0 (0.5-7.0) | 3.0 (1.0-8.0) | 3.0 (1.0-8.0) | 3.0 (1.0-8.0) | 3.0 (1.0-8.0) |
| Categorical features total | ||||||
| Sex, No. (%) | ||||||
| Male | 156 (51.7) | 44 (52.4) | 200 (51.8) | 299 (63.1) | 64 (61.0) | 363 (62.7) |
| Female | 146 (48.3) | 40 (47.6) | 186 (48.2) | 175 (36.9) | 41 (39.0) | 216 (37.3) |
| Primary tumor side, No. (%) | ||||||
| Left | 122 (40.4) | 34 (40.5) | 156 (40.4) | 267 (56.3) | 54 (51.4) | 321 (55.4) |
| Right | 131 (43.4) | 41 (48.8) | 172 (44.6) | 108 (22.8) | 26 (24.8) | 134 (23.1) |
| Rectum | 49 (16.2) | 9 (10.7) | 58 (15.0) | 99 (20.9) | 25 (23.8) | 124 (21.4) |
| Primary tumor (T) stage, No. (%) | ||||||
| T0-2 | 37 (12.3) | 10 (11.9) | 47 (12.2) | 76 (16.0) | 19 (18.1) | 95 (16.4) |
| T3-4 | 265 (87.7) | 74 (88.1) | 339 (87.8) | 398 (84.0) | 86 (81.9) | 484 (83.6) |
| Primary tumor nodal status, No. (%) | ||||||
| Yes | 202 (66.9) | 57 (67.9) | 259 (67.1) | 317 (66.9) | 72 (68.6) | 389 (67.2) |
| No | 100 (33.1) | 27 (32.1) | 127 (32.9) | 157 (33.1) | 33 (31.4) | 190 (32.8) |
| Bilobar CRLM, No. (%) | ||||||
| Yes | 159 (52.6) | 44 (52.4) | 203 (52.6) | 263 (55.5) | 51 (48.6) | 314 (54.2) |
| No | 143 (47.4) | 40 (47.6) | 183 (47.4) | 211 (44.5) | 54 (51.4) | 265 (45.8) |
| Extrahepatic disease, No. (%) | ||||||
| Yes | 49 (16.2) | 11 (13.1) | 60 (15.5) | 53 (11.2) | 6 (5.7) | 59 (10.2) |
| No | 253 (83.8) | 73 (86.9) | 326 (84.5) | 421 (88.8) | 99 (94.3) | 520 (89.8) |
| Prehepatectomy chemotherapy, No. (%) | ||||||
| Yes | 190 (62.9) | 49 (58.3) | 239 (61.9) | 307 (64.8) | 70 (66.7) | 377 (65.1) |
| No | 112 (37.1) | 35 (41.7) | 147 (38.1) | 167 (35.2) | 35 (33.3) | 202 (34.9) |
| Intraoperative ablation, No. (%) | ||||||
| Yes | 75 (24.8) | 20 (23.8) | 95 (24.6) | 123 (25.9) | 27 (25.7) | 150 (25.9) |
| No | 227 (75.2) | 64 (76.2) | 291 (75.4) | 351 (74.1) | 78 (74.3) | 429 (74.1) |
| Positive margin, No. (%) | ||||||
| Yes | 40 (13.2) | 15 (17.9) | 55 (14.2) | 73 (15.4) | 11 (10.5) | 84 (14.5) |
| No | 262 (86.8) | 69 (82.1) | 331 (85.8) | 401 (84.6) | 94 (89.5) | 495 (85.5) |
Abbreviation: CRLM, colorectal cancer liver metastases.