TABLE I.
Patient characteristics
| Characteristic | Patient 1 | Patient 2 | Patient 3 |
|---|---|---|---|
|
| |||
| Age at treatment with dupilumab (y) | 60 | 51 | 33 |
| Sex | Female | Female | Male |
| Ethnicity | African American | Caucasian | Caucasian |
| Baseline chest CT findings | Cylindrical bronchiectasis | Bilateral central bronchiectasis | Mild diffuse bronchiectasis |
| FEV1 at baseline | 1.52 L (58%) | 2.75 L (95%) | 1.97 L (37%) |
| FEV1 at 3 mo | 2.18 L (99%) | 2.82 L (97%) | 2.33 L (56%) |
| Baseline IgE (IU/L) | 561 | >2000 | 11,290 |
| IgE at 3 mo | 380 | 384 | 1637 |
| Baseline AEC | 90 | 90 | 1750 |
| AEC at 3 mo | 3400 | 160 | 690 |
AEC, Absolute eosinophil count; CT, computed tomography; FEV1, forced expiratory volume in 1 second.