Table B.5.
Available information on the detection of virus neutralising antibodies in unvaccinated animals after challenge with rabies virus All serological tests presented targeted virus neutralising antibodies
| Reference | Tissue type | Test type | Serology testing day PI | Number of samples tested |
Number of positive samples |
Titre |
Serology end (days PI) |
Study end (days PI) |
|---|---|---|---|---|---|---|---|---|
| Fekadu and Baer (1980) | Serum | RFFIT |
6–12 30 50 |
7 1 1 |
7 1 1 |
7–250 > 1,000 1,600 |
Single time point for dying dogs 50 days for surviving dog |
50 |
| CSF | RFFIT |
6–11 30 50 |
5 1 1 |
4 1 1 |
< 2–95 500 1,100 |
50 | ||
| Brain tissue | RFFIT | 8–11 | 6 | 6 | < 10–40 | 50 | ||
| Fekadu and Shaddock (1984) | ? | RFFIT | 5 | 7 | 7 | 0.3–11 IU/mL | Single time point | |
| Hanlon et al. (2002) | Serum | RFFIT |
0 3 7 11–13 |
5 5 5 5 |
5 5 5 5 |
< 5 < 5 < 5–7 13–> 56 |
13 | 13 |
| McColl et al. (2007) | Serum | RFFIT |
7 12 |
2 2 |
2 2 |
1–3 IU/mL 6.3–30 IU/mL |
12 | 42 |
| Gnanadurai et al. (2015) | Serum | RFFIT |
7 (RFFIT) 21 (RFFIT) |
4 3 |
? ? |
Mean = 0.12 IU/mL Mean = 0.32 IU/mL |
21 | 90 |
| CSF | RFFIT |
7 21 |
4 4 |
0 0 |
0 IU/mL 0 IU/mL |
21 | 90 |
CSF: cerebrospinal fluid; RFFIT: rapid fluorescent focus inhibition test.
Timeline is given as days post‐inoculation (PI).