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. 2022 Jun 2;23:458. doi: 10.1186/s13063-022-06415-5

Table 1.

Risk of bias and number of participants for the included trials

High Unclear Low No RoB

Number of trials

(total = 1659; % based on 1640 trials with risk of bias information)

1013 (62%) 494 (30%) 133 (8%) 19

Number of participants

(total = 398,410)

222,850 (55.93%) 127,290 (31.95%) 47,138 (11.83%) 1132 (0.28%)