Table 2.

Risk of bias for trials done in countries contributing 20 or more trials

Country	Number of trials	High	Unclear	Low
Multinational	193	100 (52%)	48 (25%)	45 (23%)
Australia	41	27 (66%)	10 (24%)	4 (10%)
Brazil	27	16 (59%)	10 (37%)	1 (4%)
Canada	40	26 (65%)	12 (30%)	2 (5%)
China	87	56 (64%)	23 (26%)	7 (8%)
France	31	11 (35%)	16 (52%)	4 (13%)
Germany	48	40 (83%)	7 (15%)	1 (2%)
India	48	35 (73%)	6 (13%)	5 (10%)
Iran	49	30 (61%)	18 (37%)	0 (0%)
Italy	47	30 (64%)	17 (36%)	0 (0%)
Japan	42	22 (52%)	16 (38%)	4 (10%)
Korea	32	18 (56%)	11 (34%)	1 (3%)
Netherlands	22	17 (77%)	5 (23%)	0 (0%)
Spain	29	25 (86%)	2 (7%)	1 (3%)
Sweden	26	16 (62%)	7 (27%)	2 (8%)
Turkey	32	18 (56%)	9 (28%)	2 (6%)
UK	114	63 (55%)	38 (33%)	12 (11%)
USA	280	168 (60%)	98 (35%)	12 (4%)