TABLE 2.

Monocytes/macrophages phenotypes.

	Monocyte/peripheral macrophage M0	M1 macrophage Pro-inflammatory; “classical” activation by IFNg or LPS	M2 macrophage anti-inflammatory, pro-repair; “alternative activation” by IL4
Healthy adult mouse donor	Common with homeostatic microglia: Fc, ITGAM (a-integrin=CD11b), CD200R1, CSF1R (=CD115), Iba1, ADGRE, SIRPA (=CD172a), CX3CR1
Adult mouse macrophages from bone marrow		Primary culture 1 week in GM-CSF and last 24h in LPS CD80, CD86, CD 40 IL1β, TNFα, IL6, NO, ROS, IL12, IL23, MMP1, MMP3, MMP13, ADAMTS	Primary culture 1 week in M-CSF and last 24h in IL4 CD206, CD163, Arg1, PD-L2, RELMa TGFβ, IL10, IL1-RA, IGF, MMP-1, MMP12

Summarized from Shapouri-Moghaddam et al., 2018; Orecchioni et al., 2019; Spittau et al., 2020; Miyamoto et al., 2021. Bold-italic: messengers secreted by macrophages.