Figure 1a:

General management of early systemic sclerosis

Clinically Meaningful Change:

*if >1 PFT available, a clinically meaningful decline is defined as FVC levels of >10% from baseline or decline in FVC >5% to <10% and >15% relative decline in DLCO.

Medication/Treatment Acronyms

ABT: Abatacept

CYC: Cyclophosphamide

MMF: Mycophenolate Mofetil

MTX: Methotrexate

NIN: Nintedanib

OT: Occupational Therapy

RTX: Rituximab

TCZ: Tocilizumab

Testing Acronyms

Anti-SCL-70: Anti-Topoisomerase I Antibody

CRP: C-Reactive Protein

DLco: Diffusion Capacity of Carbon Monoxide

FVC: Forced Vital Capacity

HRCT: High Resolution Chest CT

LLN: Lower Limit of Normal

PFT: Pulmonary Function Testing

Disease Acronyms

ILD: Interstitial Lung Disease

MSK: Musculoskeletal

SSc: Systemic Sclerosis