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Frequencies of SNPs (A) and iSNVs (B) by SARS-CoV-2 gene for severe (red) and mild (green) cohorts. Frequencies ≥ 0.9 were considered SNPs. Problematic sites are not included. NC signifies non-coding region of the genome. Statistical significance (p ≤ 0.05) is denoted by (*). The frequency of iSNVs in the spike gene of SARS-CoV-2 were significantly different between the severe and mild cohorts.
