Table 3.

Univariate and multivariable analyses of factors associated with PFS in the TCGA dataset (n = 268)

		Univariate analysis		Multivariate analysis
Variables		HR (95% CI)	p	HR (95% CI)	p
Sex	Female	Ref
	Male	1.592 (0.992–2.555)	0.053
Age	<70	Ref		Ref
	≥70	1.708 (1.079–2.705)	0.022	1.994 (1.233–3.222)	0.004
BMI (kg/m2)	<25	Ref
	≥25	1.454 (0.782–2.701)	0.236
	No data	0.896 (0.426–1.887)	0.774
CEA (ng/ml)	<5	NA
	≥5	NA
Tumor location	Right colon	Ref
	Left colon	0.830 (0.504–1.365)	0.464
	Rectum	1.017 (0.428–2.417)	0.969
	No data	1.662 (0.589–4.690)	0.337
Complications	No	NA
	Yes	NA
Histological grade	G1 and G2	NA
	G3, etc.	NA
LVI	Absent	Ref
	Present	1.620 (1.008–2.603)	0.046
	No data	1.338 (0.522–3.424)	0.543
LN numbers	<12	Ref		Ref
	≥12	0.629 (0.337–1.175)	0.146	0.571 (0.302–1.078)	0.084
	No data	0.323 (0.090–1.164)	0.084	0.270 (0.072–1.017)	0.053
Stage	I and II	Ref		Ref
	III	1.598 (0.945–2.702)	0.080	1.557 (0.910–2.662)	0.105
	IV	4.062 (2.241–7.361)	<0.001	3.342 (1.804–6.191)	0.0001
MSI	MSS/MSI‐low	Ref
	MSI‐high	0.873 (0.457–1.667)	0.682
	No data	1.485 (0.881–2.503)	0.137
f_wt	Continuous	0.007 (0.0002–0.2793)	0.0079
f_im200	Continuous	0.0103 (0.0005–0.1999)	0.0024	0.031 (0.001–0.645)	0.024

CEA, carcinoembryonic antigen; LN, lymph node; MSS, microsatellite stable; NA, not available; Ref, reference.