TABLE 1.
Baseline patient characteristics
| Total (N = 69) | NLR <4 (N = 36) | NLR ≥4 (N = 33) | |
|---|---|---|---|
| Age (years) | |||
| Median (range) | 61 [38–75] | 65 [50–75] | 62 [38–70] |
| <65 | 49 (71.0%) | 21 (58.3%) | 28 (84.8%) |
| ≥65 | 20 (29.0%) | 15 (41.7%) | 5 (15.2%) |
| Gender | |||
| Male | 64 (92.8%) | 33 (91.7%) | 31 (93.9%) |
| Female | 5 (7.2%) | 3 (8.3%) | 2 (6.1%) |
| ECOG PS | |||
| 0 | 47 (68.1%) | 28 (77.8%) | 19 (57.6%) |
| 1 | 22 (31.9%) | 8 (22.2%) | 14 (42.4%) |
| Smoking a | |||
| Never | 19 (27.5%) | 9 (25.0%) | 10 (30.3%) |
| Light | 15 (21.7%) | 7 (19.4%) | 8 (24.2%) |
| Heavy | 35 (50.7%) | 20 (55.6%) | 15 (45.5%) |
| Drinking | |||
| Yes | 52 (75.4%) | 28 (77.8%) | 24 (72.7%) |
| No | 17 (24.6%) | 8 (22.2%) | 9 (27.3%) |
| Disease stage | |||
| Locally advanced | 3 (4.3%) | 2 (5.6%) | 1 (3.0%) |
| Metastatic | 66 (95.7%) | 34 (94.4%) | 32 (97.0%) |
| Grade | |||
| Gx | 17 (24.6%) | 10 (27.8%) | 7 (21.2%) |
| G1 | 3 (4.3%) | 2 (5.6%) | 1 (4.3%) |
| G2 | 29 (42.0%) | 12 (33.3%) | 17 (51.5%) |
| G3 | 20 (29.0%) | 12 (33.3%) | 8 (24.2%) |
| Previous surgery | |||
| Palliative surgery | 3 (4.3%) | 1 (2.8%) | 2 (6.1%) |
| Radical esophagectomy | 26 (37.7%) | 16 (44.4%) | 10 (30.3%) |
| No | 40 (58%) | 19 (52.8%) | 21 (63.6%) |
| Previous radiotherapy | |||
| Yes | 46 (66.7%) | 20 (55.6%) | 26 (78.8%) |
| No | 23 (33.3%) | 16 (44.4%) | 7 (21.2%) |
| Line of prior chemotherapy | |||
| (0–1) | 44 (63.8%) | 24 (66.7%) | 20 (60.6%) |
| ≥2 | 25 (36.2%) | 12 (33.3%) | 13 (39.4%) |
| PD‐L1 TPS | |||
| ≥10% | 22 (31.9%) | 15 (41.7%) | 7 (21.2%) |
| <10% | 42 (60.9%) | 18 (50%) | 24 (72.7%) |
| NA | 5 (7.2%) | 3 (8.3%) | 2 (6.1%) |
| HLA‐I | |||
| Homozygosity | 11 (15.9%) | 7 (19.4%) | 4 (12.1%) |
| Heterozygosity | 58 (84.1%) | 29 (80.6%) | 29 (87.9%) |
Abbreviations: ECOG PS, Eastern Cooperative Oncology Group performance status; HLA‐I, human leukocyte antigen class I; NLR, neutrophil to lymphocyte ratio; PD‐L1, programmed death receptor ligand 1; TPS, tumor proportion score.
a
Classification of smoking history as follows: never, light (≤20 pack‐years), heavy (>20 pack‐years).