TABLE 1.

Summary of sEVs-ncRNAs involved in OC carcinogenesis.

sEVs-ncRNAs	Source	Recipient Cells	Roles/Mechanisms	References
miR-6780b-5p	Ascites	OC cells	Induces epithelial–mesenchymal transition of OC cells	Cai et al. (2021)
miR-330-3p	Plasma cells	OC cells	Promotes core epithelial-mesenchymal transition programs	Yang et al. (2021b)
lncRNA SPOCD1-AS	OC cells	Peritoneal mesothelial cells	Remodels mesothelial cells via interacting with G3BP1	Wang et al. (2021a)
circWHSC1	OC cells	Peritoneal mesothelial cells	Sponges miR-145 and miR-1182 to promote proliferation and invasion of OC cells	Zong et al. (2019)
circPUM1	OC cells	Peritoneal mesothelial cells	Sponges miR-615-5p and miR-6753-5p to inhibit apoptosis via up-regulating NF-κB and MMP2	Guan et al. (2019)
miR-630	OC cells	Normal fibroblasts	Facilitates CAFs activation	Cui et al. (2021)
miR-221-3p	M2-phenotype macrophages	OC cells	Promotes proliferation and G1/S transition of OC cells	Li and Tang, (2020)
miR-21-3p, miR-125b-5p, miR-181d-5p
miR-940	Hypoxic OC cells	Macrophages	Induce polarization of M2-phenotype macrophages	(Chen et al., 2017; Chen et al., 2018)
miR-29a-3p
miR-21-5p	TAMs	CD4+ T cells	Suppress STAT3 and result in the imbalance of Treg/Th17 cells	Zhou et al. (2018)
miR-141-3p	OC cells	HUVECs	Promotes endothelial cells migration and angiogenesis	Masoumi-Dehghi et al. (2020)
miR-205	OC cells	HUVECs	Increases microvessel density	He et al. (2019)

OC, ovarian cancer; CAFs, cancer-associated fibroblasts; TAMs, tumor-associated macrophages; HUVECs, human umbilical vein endothelial cells.