Table 2.
Pharmacokinetic profile of ATV006 in Sprague-Dawley rats and cynomolgus monkeys. ATV006 was administered by the indicated route, and the parameters were calculated based on the LC-MS/MS analysis of the parent nucleoside, GS-441524 (n=3 per group).
| rat | monkey | |||
| parameters | IV (5 mg/kg) | Oral (25 mg/kg) |
IV (5 mg/kg) | Oral (10 mg/kg) |
| AUClast (μM*h) | 5.6 ± 1.6 | 22.8 ± 4.6 | 20.46 ± 1.68 | 12.22 ± 0.84 |
| T1/2 (h) | 1.5 ± 0.2 | 1.2 ± 0.1 | 1.78 ± 0.6 | 4.08 ± 0.94 |
| Tmax (h) | 0.5 ± 0.25 | 0.083 | 1.50 ± 2.20 | |
| Cmax (μM) | 8.7 ± 7.8 | 8.2 ± 0.8 | 12.82 ± 2.43 | 3.71 ± 2.24 |
| F (%) | 81.5 ± 15.6% | 30.08% | ||