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Pharmacokinetic profile of GS-441524 in Sprague-Dawley rats. GS-441524 was administered by the indicated route, and the parameters were calculated based on the LC-MS/MS analysis of GS-441524 (n=3 per group).
| rat | ||
| parameters | IV (5 mg/kg) | Oral (25 mg/kg) |
| AUClast (μM*h) | 11.0 ± 1.7 | 11.7 ± 5.1 |
| T1/2 (h) | 1.2 ± 0.1 | 1.4 ± 0.2 |
| Tmax (h) | 1.00 ± 0.3 | |
| Cmax (μM) | 10.7 ± 1.5 | 3.4 ± 0.5 |
| F (%) | 21.7 ± 9.7% | |
