Table 4.
PK parameters of GS-441524, RMP, and RTP in rat plasma and tissues after oral administration of ATV006 or GS-441524 100 mg/kg.
| Administration | Compound | Source | Tmax | Cmax | AUClast |
| (h) | (μmol/L or μmol/kg) | (h*μmol/L or h*μmol/kg) | |||
| ATV006 | GS-441524 | plasma | 1.00 | 38.687 | 126.172 |
| brain | 1.00 | 1.019 | 4.335 | ||
| lung | 1.00 | 41.071 | 142.339 | ||
| liver | 1.00 | 48.716 | 239.494 | ||
| kidney | 1.00 | 190.013 | 661.392 | ||
| RMP | lung | 4.00 | 0.620 | 9.376 | |
| liver | 1.00 | 9.579 | 97.243 | ||
| kidney | 1.00 | 6.147 | 51.416 | ||
| RTP | lung | 4.00 | 0.310 | 5.966 | |
| liver | 4.00 | 1.154 | 18.553 | ||
| kidney | 4.00 | 0.295 | 3.205 | ||
| GS-441524 | GS-441524 | plasma | 1.00 | 5.632 | 31.294 |
| brain | 24.0 | 0.073 | 0.822 | ||
| lung | 1.00 | 5.601 | 34.327 | ||
| liver | 1.00 | 8.776 | 124.688 | ||
| kidney | 1.00 | 35.165 | 199.702 | ||
| RMP | lung | 0 | 0 | ||
| liver | 4.00 | 1.767 | 19.680 | ||
| kidney | 1.00 | 0.554 | 1.913 | ||
| RTP | lung | 4.00 | 0.024 | 0.418 | |
| liver | 4.00 | 0.088 | 1.562 | ||
| kidney | 0 | 0 |