(A) Intra-tumoral structure CV values from 1.5 cm × 1.5 cm tumor-bearing ROIs shown in figure 4. (B) Tumor boundary CV values from 2.0 cm × 2.0 cm ROIs shown in figure 5. (C) TBCR values quantified in 2 mm diameter samples on either side of the tissue boundary (solid colored dots in figure 5 column 1).DWL Lum. = diffuse white light luminance; scatter = 490 nm optical scatter; Ca = carcinoma; IDCa, LG = invasive ductal carcinoma, low grade; IDCa, IG = invasive ductal carcinoma, intermediate grade; IDCa, IG = invasive ductal carcinoma, high grade; ILCa = invasive lobular carcinoma.