Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic representation of fibrotic cells carrying GF, TGF-β, and αVβ6 integrin receptors. The small molecules GSK3008348 and PLN-74809 are αVβ6 integrin antagonists that inhibit integrin binding to LAPm thus preventing the active TGF-β release and profibrotic signaling events; nintedanib inhibits the tyrosine kinase activity of GF receptors and prevents downstream intracellular signaling events.
